About CMAT

The CMAT (Correlated Mutation Analysis Tool) is a fully automated and reliable web-server for correlated mutation analysis.

CMAT automatically performs all the processes for correlated mutation analysis including homology search, multiple sequence alignment construction, sequence redundancy treatment, and various correlated mutation score measures.

By incorporating sequence profile, CMAT reliably estimates the joint probabilities that most correlated mutation measures are derived from. The adjustment consistently improves various correlated mutation measures regardless of the quality of the input alignments.

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Chan-Seok Jeong and Dongsup Kim (2012) Reliable and robust detection of coevolving protein residues. Protein Eng. 25, 705–713.


The CMAT server is developed and maintained at the Bioinformatics and Computational Biology Laboratoty, Korea Advanced Institute of Science and Technology (KAIST).

Please inform us of any problems and comments with this service for the continual improvements.